专利名称：METHOD FOR NON-INVASIVE PRENATAL
DIAGNOSIS
发明人：Charles R. Cantor,Chunming Ding,Yuk Ming
Dennis Lo,Rossa Wai Kwum Chiu
申请号：US13369000申请日：20120208
公开号：US20120225798A1公开日：20120906
摘要：The present invention is directed to methods of detecting nucleic acids in abiological sample. The method is based on a novel combination of a base extensionreaction, which provides excellent analytical specificity, and a mass spectrometric analysis,which provides excellent specificity. The method can be used, for example, for diagnostic,prognostic and treatment purposes. The method allows accurate detection of nucleicacids that are present in very small amounts in a biological sample. For example, themethod of the present invention is preferably used to detect fetal nucleic acid in amaternal blood sample; circulating tumor-specific nucleic acids in a blood, urine or stoolsample; and donor-specific nucleic acids in transplant recipients. In another embodiment,one can detect viral, bacterial, fungal, or other foreign nucleic acids in a biological sample.
申请人：Charles R. Cantor,Chunming Ding,Yuk Ming Dennis Lo,Rossa Wai Kwum Chiu
地址：Del Mar CA US,Singapore SG,Hong Kong CN,Hong Kong CN
国籍：US,SG,CN,CN
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